Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 116, Issue 9, Pages 1807-1815Publisher
WILEY
DOI: 10.1002/jcb.24679
Keywords
miRNAs; ANGIOGENESIS; CANCER
Categories
Funding
- Natural Science Foundation of Jiangsu Province [BK20130395]
- National Natural Science Foundation of China [81402189]
- Open Foundation of Jiangsu Province Key Laboratory of Tumor Biological Therapy [ZL1201]
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Angiogenesis, the process of new blood vessel formation and growth from already existing venules is critical in vascular development and homeostasis controlled by the balance of pro- and anti-angiogenic factors. Emerging evidence indicates the development, progression, and metastasis of various human cancers are strongly relied on angiogenesis. However, molecular mechanisms that underlie the complex regulation of angiogenic processes are still not fully elucidated. Recent studies revealed that microRNAs (miRNAs) were important regulators of tumor angiogenesis and the entire research in this area has entered into a so-called miRNAs era. Thus, miRNAs might be important therapeutic targets or biomarkers for cancer. Due to the complexity of miRNA regulating mechanisms, how specific miRNAs intersect with and modulate tumor angiogenesis is still unclear. The conflicting results of the same miRNAs from different groups indicated that miRNAs might possess potent activity in a cell type or cell context specific manner. Here, we present a summary of latest advances in understanding the roles of angiogenic miRNAs as potential tools or targets in cancer therapy. J. Cell. Biochem. 116: 1807-1815, 2015. (c) 2013 Wiley Periodicals, Inc.
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