Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 16, Issue 15, Pages 7102-7106Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.06.054
Keywords
pyrazole; pyrazolo[3,4-d] pyrimidine; S- and N-nucleosides; antiviral activity
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Some novel substituted pyrazole and pyrazolo[3,4-d] pyrimidine derivatives 2, 4, 8, and 9 were synthesized. Also, some acyclic S-nucleosides of pyrazolo[3,4-d] pyrimidine derivatives 10 -13 were prepared via reaction of pyrazolo[3,4-d] pyrimidine-4(3H)-thione derivative 9 with some acyclic sugars. Moreover, the N-nucleoside derivative 14 was prepared via reaction of compound 8 with glucosamine hydrochloride. The antiviral evaluation of some selected new products showed that they have promising antiviral activity against hepatitis-A virus (HAV) and herpes simplex virus type-1 (HSV-1). (C) 2008 Elsevier Ltd. All rights reserved.
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