Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 16, Issue 21, Pages 9467-9470Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.09.044
Keywords
Mushroom; Hericium erinaceum; Endoplasmic reticulum stress suppression; Hericenone; Neurodegenerative disease
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [17035037]
- Grants-in-Aid for Scientific Research [17035037] Funding Source: KAKEN
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Three new compounds, 3-hydroxyhericenone F (1), hericenone I (2), and hericenone J (3), were isolated from the mushroom Hericium erinaceum. The structures of 1-3 were determined by the interpretation of spectral data. Compound 1 showed the protective activity against endoplasmic reticulum (ER) stress-dependent Neuro2a cell death, however, compounds 2 and 3 did not. (C) 2008 Elsevier Ltd. All rights reserved.
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