Lignanamides from the stems of Piper hancei maxim. and their anti-inflammatory and cytotoxic activities

Four new lignanamides, hancamides A -D (1-4), together with four known analogs (5-8), were isolated from the stems of Piper hancei Maxim. Their structures were determined based on 1D and 2D NMR, IR, UV, and HRESIMS spectroscopic analysis as well as by comparison with the reported data. All the isolates exhibited potential inhibitory effects on NO production in LPS-induced BV-2 microglial cells, with IC50 values of 4.26-40.68 mu M. Moreover, compounds 2 and 8 displayed moderate cytotoxic activities against MGC-803, HepG2, SKOV-3, T24, and HeLa cells, with IC50 values ranging from 13.57 to 34.20 mu M, respectively.

Automated summary

In this study, four new lignanamides and four known analogs were isolated from the stems of Piper hancei Maxim. These compounds exhibited potential inhibitory effects on NO production in BV-2 microglial cells and moderate cytotoxic activities against certain types of cells.