Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 16, Issue 3, Pages 1073-1083Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2007.10.026
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Funding
- NIAID NIH HHS [R01 AI072155, R01 AI072155-01] Funding Source: Medline
- NIGMS NIH HHS [R37 GM044154, R37 GM044154-19] Funding Source: Medline
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The processing and presentation of lipid antigens by antigen presenting cells (APC) is important for defense against infection, tumor immunosurveillance, and autoimmunity. CD1, a family of cell surface glycoproteins, is responsible for the binding and presentation of lipid antigens to receptors expressed on the surface of T lymphocytes. Among the several (glyco)lipids identified to cause T-cell stimulation in complex with CD1, alpha-galactosyl ceramide (alpha-GalCer) is one of the most well studied. A combination of structure-activity relationship (SAR), crystallographic studies, and discovery of new 'natural' antigens has led to greater understanding of the structural requirements for optimal natural killer T-cell activation. (c) 2007 Elsevier Ltd. All rights reserved.
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