Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 16, Issue 5, Pages 2550-2557Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2007.11.048
Keywords
antitumor agents; combretastatin A-4; imidazol-2-one derivatives; synthesis; cytotoxicity
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A new series of aryl substituted imidazol-2-one derivatives structurally related to combretastatin A-4 (CA-4) were synthesized and evaluated for their cytotoxic activities in vitro against various human cancer cell lines including MDR cell line. The cytotoxic effects of compounds 7b and 7i proved to be similar to or greater than that of docetaxel. The highly active compound 7b also exhibited excellent inhibitory activity on tumor growth in vivo. (C) 2008 Published by Elsevier Ltd.
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