4.7 Review

Extracellular vesicles in (3 cell biology: Role of lipids in vesicle biogenesis, cargo, and intercellular signaling

Related references

Note: Only part of the references are listed.
Review Spectroscopy

Enriching extracellular vesicles for mass spectrometry

Jordan B. Burton et al.

Summary: Extracellular vesicles, particularly exosomes, have great potential as biomarkers for health and cell activity status. Effective enrichment of exosomes is essential for analysis and high throughput approaches are achievable.

MASS SPECTROMETRY REVIEWS (2023)

Review Endocrinology & Metabolism

Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement

Carlos Salomon et al.

Summary: The hormone-like role of extracellular vesicles (EVs) in cell-to-cell communication has gained significant interest in the past decade. EVs, as a heterogeneous population of membrane-bound vesicles, carry endocrine signals and play a role in various biological activities. They can also serve as indicators of diseases. This article aims to highlight the importance of EV research and its potential role in the field of endocrinology.

ENDOCRINE REVIEWS (2022)

Article Cell Biology

Uptake, functionality, and re-release of extracellular vesicle-encapsulated cargo

Killian O'Brien et al.

Summary: Extracellular vesicles (EVs) are membrane-encapsulated particles carrying genetically active and protein/lipid cargo that can impact recipient cell function. This study demonstrates the functional delivery of EV-encapsulated RNA and protein cargo using luminescence and fluorescence reporters. The research highlights the retention of internalized cargo in the endosomal compartment and the re-release of intact EVs by recipient cells. These findings shed light on critical factors in cargo delivery and enhance the therapeutic potential of EVs.

CELL REPORTS (2022)

News Item Biotechnology & Applied Microbiology

Exosome-based candidates move into the clinic

Megan Cully

Summary: Exosomes, small extracellular vesicles shed by cells, have long been considered promising drug delivery systems for various biologic payloads, with the first ones now in clinical trials.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Cell & Tissue Engineering

Ultrafiltration and Injection of Islet Regenerative Stimuli Secreted by Pancreatic Mesenchymal Stromal Cells

Tyler T. Cooper et al.

Summary: The study demonstrates that intrapancreatic injection of concentrated CM produced by MSCs can support islet regeneration and glycemic control. Using Panc-MSC as biofactories, the research shows potential applications for regenerative medicine by enriching tissue regenerative stimuli housed within the secretome.

STEM CELLS AND DEVELOPMENT (2021)

Review Chemistry, Multidisciplinary

Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering

Fei Teng et al.

Summary: Extracellular vesicles (EVs) are nano-sized secreted vesicles containing various biomolecules, which have low immunogenicity and can functionally modify recipient cells by transferring bioactive constituents. Therefore, they are considered as an excellent candidate for the next generation drug delivery system.

ADVANCED SCIENCE (2021)

Article Biochemistry & Molecular Biology

Alterations in β-Cell Sphingolipid Profile Associated with ER Stress and iPLA2β: Another Contributor to β-Cell Apoptosis in Type 1 Diabetes

Tomader Ali et al.

Summary: The development of Type 1 diabetes is partly due to ER stress-induced beta-cell apoptosis, where iPLA(2)beta plays a significant role in the generation of pro-apoptotic ceramides. The study suggests that the shift in the beta-cell sphingolipid profile mediated by iPLA(2)beta could contribute to beta-cell death associated with T1D.

MOLECULES (2021)

Article Medicine, Research & Experimental

Adipocyte-derived extracellular vesicles regulate survival and function of pancreatic β cells

Iacopo Gesmundo et al.

Summary: Healthy adipocyte-derived EVs are beneficial for beta cell survival and function, while EVs from inflamed adipocytes cause beta cell death and dysfunction. Lean adipocyte-derived EVs have similar beneficial effects, whereas EVs from obese adipose tissue are harmful for beta cells. Differential expression of miRNAs and alterations in signaling pathways and gene expression in recipient beta cells were observed, suggesting that adipocyte-derived EVs may influence beta cell fate and function depending on the physiological and pathological state of adipose tissue.

JCI INSIGHT (2021)

Review Cell Biology

The exosome journey: from biogenesis to uptake and intracellular signalling

Sonam Gurung et al.

Summary: Exosomes have vast potential in clinical applications, and understanding their biology is crucial. The processes of exosome biogenesis, transport, and uptake involve numerous influencing factors.

CELL COMMUNICATION AND SIGNALING (2021)

Article Biochemistry & Molecular Biology

ALIX and ceramide differentially control polarized small extracellular vesicle release from epithelial cells

Takahide Matsui et al.

Summary: The study demonstrates that different types of small extracellular vesicles, known as exosomes, are differentially secreted from the apical and basolateral sides of polarized epithelial cells. Two independent machineries are responsible for the polarized exosome release from epithelial cells.

EMBO REPORTS (2021)

Meeting Abstract Oncology

SELECTIVE EXPANSION OF ANTIGEN-SPECIFIC CD8 T CELLS WITH ENGINEERED ANTIGEN PRESENTING EXOSOME

Tomoyoshi Yamano et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Review Nanoscience & Nanotechnology

Biogenesis, Membrane Trafficking, Functions, and Next Generation Nanotherapeutics Medicine of Extracellular Vesicles

Sangiliyandi Gurunathan et al.

Summary: Extracellular vesicles (EVs) are a diverse group of membrane-bound vesicles that function as messengers between cells. Much remains unknown about their biogenesis, cargo sorting, and potential therapeutic applications.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

Article Biochemistry & Molecular Biology

Phosphatidylcholine-Engineered Exosomes for Enhanced Tumor Cell Uptake and Intracellular Antitumor Drug Delivery

Qi Zhan et al.

Summary: This study demonstrated the importance of engineering exosomal lipids to enhance cancer cellular uptake, leading to improved tumor cell internalization and increased anti-tumor activity in vitro.

MACROMOLECULAR BIOSCIENCE (2021)

Review Genetics & Heredity

Omics Approaches for Understanding Biogenesis, Composition and Functions of Fungal Extracellular Vesicles

Daniel Zamith-Miranda et al.

Summary: Omics technologies play a crucial role in elucidating the biology of fungal EVs, revealing their composition, biogenesis, and function. These structures serve various functions, from being key carriers of cell wall biosynthetic machinery to potentially acting as virulence factors. The integration of omics with genetic approaches is instrumental in determining both the biogenesis and cargo loading into EVs.

FRONTIERS IN GENETICS (2021)

Review Biochemistry & Molecular Biology

Regulation of Tissue Inflammation by 12-Lipoxygenases

Abhishek Kulkarni et al.

Summary: 12-LOX is a key lipid metabolizing enzyme that plays an important role in inflammatory diseases. Increased activity of 12-LOX can lead to tissue damage and enhanced migration of immune cells, while inhibition of this enzyme can protect against disease development and progression in animal models.

BIOMOLECULES (2021)

Article Endocrinology & Metabolism

β-Cell autophagy in the pathogenesis of type 1 diabetes

Charanya Muralidharan et al.

Summary: Type 1 diabetes is an insulin-dependent autoimmune disease characterized by destruction of pancreatic beta cells leading to hyperglycemia. Research suggests that defects in autophagy may be linked with beta-cell dysfunction in type 1 diabetes, sparking investigations into the role of this mechanism in disease pathogenesis.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2021)

Review Endocrinology & Metabolism

Extracellular Vesicles-The Next Frontier in Endocrinology

Anasuya Das Gupta et al.

Summary: Extracellular vesicles, including exosomes, play important roles in normal physiology and disease states by delivering signals through membrane-bound particles in body fluids. Similar to the endocrine system, the EV system is likely under homeostatic control, making the regulation of their biogenesis and secretion crucial for further exploration.

ENDOCRINOLOGY (2021)

Review Cell Biology

The role of lipids in exosome biology and intercellular communication: Function, analytics and applications

Javier Donoso-Quezada et al.

Summary: Exosomes are important extracellular vesicles with compositions related to the progression of various diseases. Lipids, as crucial components of exosomes, play significant roles in exosome biology and intercellular communication. Exosome lipidomics is an emerging discipline that offers insights into the discovery of new lipid species for biomedical applications.

TRAFFIC (2021)

Article Multidisciplinary Sciences

Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9

Mathilde Mathieu et al.

Summary: This study tracks the intracellular trafficking of two proteins before their secretion in EVs, reporting the biogenesis and protein markers of EV subtypes: ectosomes budding from the plasma membrane as well as exosomes from late endosomes.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Withaferin A inhibits lymphocyte proliferation, dendritic cell maturation in vitro and prolongs islet allograft survival

Kenjiro Kumano et al.

Summary: Withaferin A may reduce inflammation and prolong allograft survival by inhibiting dendritic cell maturation and T-cell proliferation.

SCIENTIFIC REPORTS (2021)

Article Cell Biology

Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes

Naureen Javeed et al.

Summary: The study demonstrates that pro-inflammatory beta cell-derived small EVs disrupt beta cell function, promote inflammatory responses, and enhance immune cell recruitment in the islets. Furthermore, CXCL10 chemokine enriched in these EVs binds to CXCR3 receptors on beta cells, modulating inflammatory gene expression and leukocyte recruitment.

CELL REPORTS (2021)

Review Biotechnology & Applied Microbiology

Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors

Mona G. Alharbi et al.

Summary: Extracellular vesicles (EVs), such as exosomes, are nanosized membrane-enveloped vesicles containing diverse bioactive cargo. EVs derived from stem cells can be preconditioned to produce vesicles with different therapeutic properties, particularly with respect to heat-shock proteins. Heat-shock proteins play crucial roles in cellular protection and resistance to various therapeutic treatments.

BIOMED RESEARCH INTERNATIONAL (2021)

Review Immunology

Extracellular Vesicles in Immune System Regulation and Type 1 Diabetes: Cell-to-Cell Communication Mediators, Disease Biomarkers, and Promising Therapeutic Tools

Giuseppina Emanuela Grieco et al.

Summary: EVs are generated by cells through complex molecular mechanisms and contain molecular cargo such as ncRNA, mRNA, and proteins that modulate biological processes and are altered in diseases including autoimmune diseases. EVs have a promising role as biomarkers in disease progression, with studies showing specific cargo alterations in autoimmune diseases like T1D.

FRONTIERS IN IMMUNOLOGY (2021)

Review Endocrinology & Metabolism

Role of Exosomes in Islet Transplantation

Jordan Mattke et al.

Summary: Exosomes play a crucial role in studying diagnostic markers for islet cell viability and function in islet transplantation. They may have an impact on the success of islet transplantation and could potentially be used as a therapeutic tool.

FRONTIERS IN ENDOCRINOLOGY (2021)

Review Biotechnology & Applied Microbiology

Mechanism of cargo sorting into small extracellular vesicles

Yiwen Chen et al.

Summary: Extracellular vesicles are membranous structures released by cells to transport biomolecules and signaling molecules between cells, with small sEVs and larger EVs being the two main types categorized by size. These vesicles are no longer considered waste products, but rather regulators of intercellular communication with specific cargos sorted into them through different mechanisms.

BIOENGINEERED (2021)

Article Biochemistry & Molecular Biology

Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase

Annalisa Contursi et al.

Summary: Platelets induce the generation of primarily esterified 12-HETE in colon cancer cells through the delivery of 12-LOX, impacting cancer cell biology and providing a potential target for anticancer therapy.

JOURNAL OF LIPID RESEARCH (2021)

Article Pharmacology & Pharmacy

Engineered extracellular vesicles with synthetic lipids via membrane fusion to establish efficient gene delivery

Yong-Yu Jhan et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Review Biochemistry & Molecular Biology

Lipid Rafts in Exosome Biogenesis

G. O. Skryabin et al.

BIOCHEMISTRY-MOSCOW (2020)

Review Biochemistry & Molecular Biology

Engineering Extracellular Vesicles as Nanotherapeutics for Regenerative Medicine

Lalithasri Ramasubramanian et al.

BIOMOLECULES (2020)

Review Pharmacology & Pharmacy

An emerging focus on lipids in extracellular vesicles

Tore Skotland et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Review Biochemistry & Molecular Biology

Synergies in exosomes and autophagy pathways for cellular homeostasis and metastasis of tumor cells

Leila Salimi et al.

CELL AND BIOSCIENCE (2020)

Review Immunology

Post-translational Modification Regulates Formation and Cargo-Loading of Extracellular Vesicles

Jonathan M. Carnino et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Cell Biology

Extracellular Vesicles Derived Human-miRNAs Modulate the Immune System in Type 1 Diabetes

Tine Tesovnik et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Endocrinology & Metabolism

The Role of Extracellular Vesicles in β-Cell Function and Viability: A Scoping Review

Stephanie Chidester et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Review Cell Biology

Sphingolipids in Type 1 Diabetes: Focus on Beta-Cells

Ewa Gurgul-Convey

CELLS (2020)

Article Biochemistry & Molecular Biology

A 12-lipoxygenase-Gpr31 signaling axis is required for pancreatic organogenesis in the zebrafish

Marimar Hernandez-Perez et al.

FASEB JOURNAL (2020)

Article Cell Biology

Mammalian stress granules and P bodies at a glance

Claire L. Riggs et al.

JOURNAL OF CELL SCIENCE (2020)

Review Endocrinology & Metabolism

Role of the PD-1/PD-L1 Dyad in the Maintenance of Pancreatic Immune Tolerance for Prevention of Type 1 Diabetes

Marika Falcone et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Article Medicine, Research & Experimental

Lipid mediators and biomarkers associated with type 1 diabetes development

Alexander J. Nelson et al.

JCI INSIGHT (2020)

Article Cell Biology

Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes

Peter J. Thompson et al.

CELL METABOLISM (2019)

Article Nanoscience & Nanotechnology

Decoy exosomes as a novel biologic reagent to antagonize inflammation

Natalie Duong et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Review Biochemistry & Molecular Biology

Exosomes

D. Michiel Pegtel et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 88 (2019)

Article Multidisciplinary Sciences

The generation and use of recombinant extracellular vesicles as biological reference material

Edward Geeurickx et al.

NATURE COMMUNICATIONS (2019)

Article Neurosciences

Inhibition of nSMase2 Reduces the Transfer of Oligomeric α-Synuclein Irrespective of Hypoxia

Valerie Sackmann et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Article Biochemistry & Molecular Biology

Profiling of RNAs from Human Islet-Derived Exosomes in a Model of Type 1 Diabetes

Preethi Krishnan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Endothelial acid ceramidase in exosome-mediated release of NLRP3 inflammasome products during hyperglycemia: Evidence from endothelium-specific deletion of Asah1 gene

Xinxu Yuan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2019)

Article Biochemical Research Methods

Microfluidic on-demand engineering of exosomes towards cancer immunotherapy

Zheng Zhao et al.

LAB ON A CHIP (2019)

Review Chemistry, Multidisciplinary

Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools

Song-pei Li et al.

ACTA PHARMACOLOGICA SINICA (2018)

Article Cell Biology

Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise

Martin Whitham et al.

CELL METABOLISM (2018)

Review Biochemistry & Molecular Biology

Role of sphingolipids in the biogenesis and biological activity of extracellular vesicles

Claudia Verderio et al.

JOURNAL OF LIPID RESEARCH (2018)

Review Biochemistry & Molecular Biology

Phospholipase D and phosphatidic acid in the biogenesis and cargo loading of extracellular vesicles

Antonio Luis Egea-Jimenez et al.

JOURNAL OF LIPID RESEARCH (2018)

Review Biochemistry & Molecular Biology

Cholesterol and the journey of extracellular vesicles

Frank W. Pfrieger et al.

JOURNAL OF LIPID RESEARCH (2018)

Review Biochemistry & Molecular Biology

Extracellular vesicles and their content in bioactive lipid mediators: more than a sack of microRNA

Eric Boilard

JOURNAL OF LIPID RESEARCH (2018)

Review Biochemistry & Molecular Biology

Extracellular vesicles: lipids as key components of their biogenesis and functions

Michel Record et al.

JOURNAL OF LIPID RESEARCH (2018)

Article Cell Biology

Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy

Xianjun Gao et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

Article Multidisciplinary Sciences

Efficient RNA drug delivery using red blood cell extracellular vesicles

Waqas Muhammad Usman et al.

NATURE COMMUNICATIONS (2018)

Article Chemistry, Analytical

In Vivo Tracking of Multiple Tumor Exosomes Labeled by Phospholipid-Based Bioorthogonal Conjugation

Pengjuan Zhang et al.

ANALYTICAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Lipidomic profiling of extracellular vesicles derived from prostate and prostate cancer cell lines

Joshua S. Brzozowski et al.

LIPIDS IN HEALTH AND DISEASE (2018)

Review Neurosciences

Sphingolipid-Enriched Extracellular Vesicles and Alzheimer's Disease: A Decade of Research

Michael B. Dinkins et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Article Multidisciplinary Sciences

Extracellular vesicles from human pancreatic islets suppress human islet amyloid polypeptide amyloid formation

Diana Ribeiro et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Biochemistry & Molecular Biology

Lipids in exosomes: Current knowledge and the way forward

Tore Skotland et al.

PROGRESS IN LIPID RESEARCH (2017)

Review Immunology

The role of the LTB4-BLT1 axis in chemotactic gradient sensing and directed leukocyte migration

Bhagawat C. Subramanian et al.

SEMINARS IN IMMUNOLOGY (2017)

Review Endocrinology & Metabolism

MicroRNA expression profiles and type 1 diabetes mellitus: systematic review and bioinformatic analysis

Tais S. Assmann et al.

ENDOCRINE CONNECTIONS (2017)

Review Clinical Neurology

Alpha-synuclein oligomers: a new hope

Nora Bengoa-Vergniory et al.

ACTA NEUROPATHOLOGICA (2017)

Article Endocrinology & Metabolism

MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells

Emily K. Sims et al.

DIABETOLOGIA (2017)

Review Cardiac & Cardiovascular Systems

Methodological Guidelines to Study Extracellular Vesicles

Frank A. W. Coumans et al.

CIRCULATION RESEARCH (2017)

Article Biochemistry & Molecular Biology

Development of exosome surface display technology in living human cells

Zachary Stickney et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

PIKfyve inhibition increases exosome release and induces secretory autophagy

Nina Pettersen Hessvik et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Article Gastroenterology & Hepatology

Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes

Petra Hirsova et al.

GASTROENTEROLOGY (2016)

Article Biochemistry & Molecular Biology

Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line

Maria Podbielska et al.

JOURNAL OF LIPID RESEARCH (2016)

Editorial Material Neurosciences

Port-to-Port Delivery: Mobilization of Toxic Sphingolipids Via Extracellular Vesicles

Giuseppe Scesa et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2016)

Article Biochemistry & Molecular Biology

Exosomes Mediate LTB4 Release during Neutrophil Chemotaxis

Ritankar Majumdar et al.

PLOS BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes

Luciano Ribeiro Filgueiras et al.

SCIENCE SIGNALING (2015)

Article Biochemistry & Molecular Biology

Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes

Luciano Ribeiro Filgueiras et al.

SCIENCE SIGNALING (2015)

Article Oncology

Pancreatic Cancer-Derived Exosomes Cause Paraneoplastic β-cell Dysfunction

Naureen Javeed et al.

CLINICAL CANCER RESEARCH (2015)

Article Biochemistry & Molecular Biology

The Ether Lipid Precursor Hexadecylglycerol Stimulates the Release and Changes the Composition of Exosomes Derived from PC-3 Cells

Santosh Phuyal et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Review Immunology

Eicosanoid storm in infection and inflammation

Edward A. Dennis et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Review Biochemistry & Molecular Biology

Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies

Michel Record et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2014)

Review Biochemistry & Molecular Biology

Emerging concepts on the role of exosomes in lipid metabolic diseases

Michel Record et al.

BIOCHIMIE (2014)

Article Biochemical Research Methods

Surface Functionalization of Exosomes Using Click Chemistry

Tyson Smyth et al.

BIOCONJUGATE CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Regulation of exosome release by glycosphingolipids and flotillins

Santosh Phuyal et al.

FEBS JOURNAL (2014)

Article Multidisciplinary Sciences

Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

Rania Ghossoub et al.

NATURE COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

Molecular lipidomics of exosomes released by PC-3 prostate cancer cells

Alicia Llorente et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2013)

Article Endocrinology & Metabolism

Decreased Cord-Blood Phospholipids in Young Age-at-Onset Type 1 Diabetes

Daria La Torre et al.

DIABETES (2013)

Article Biochemistry & Molecular Biology

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

Nobuyoshi Kosaka et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biotechnology & Applied Microbiology

Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

Yuki Takahashi et al.

JOURNAL OF BIOTECHNOLOGY (2013)

Article Biochemical Research Methods

Distinct lipid compositions of two types of human prostasomes

Jos F. Brouwers et al.

PROTEOMICS (2013)

Article Cell Biology

Lipid Sorting and Multivesicular Endosome Biogenesis

Christin Bissig et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Article Multidisciplinary Sciences

Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes

Taketoshi Kajimoto et al.

NATURE COMMUNICATIONS (2013)

Review Genetics & Heredity

Signaling Pathways in Exosomes Biogenesis, Secretion and Fate

Lorena Urbanelli et al.

GENES (2013)

Article Endocrinology & Metabolism

Role of calcium-independent phospholipase A2β in human pancreatic islet β-cell apoptosis

Xiaoyong Lei et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2012)

Article Cell Biology

Syndecan-syntenin-ALIX regulates the biogenesis of exosomes

Maria Francesca Baietti et al.

NATURE CELL BIOLOGY (2012)

Article Biochemical Research Methods

Exosome-mediated delivery of siRNA in vitro and in vivo

Samir El-Andaloussi et al.

NATURE PROTOCOLS (2012)

Article Biochemistry & Molecular Biology

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

Jessica Wahlgren et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Multidisciplinary Sciences

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein

Joseph F. Nabhan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Cell Biology

The ESCRT Pathway

William M. Henne et al.

DEVELOPMENTAL CELL (2011)

Review Cell Biology

Regulation of PIP5K Activity by Arf6 and Its Physiological Significance

Yuji Funakoshi et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2011)

Article Biochemistry & Molecular Biology

Circulating sphingolipid biomarkers in models of type 1 diabetes

Todd E. Fox et al.

JOURNAL OF LIPID RESEARCH (2011)

Article Multidisciplinary Sciences

Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3

Thiha Aung et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

Maria Mittelbrunn et al.

NATURE COMMUNICATIONS (2011)

Article Biochemistry & Molecular Biology

The leukotriene B4 receptor, BLT1, is required for the induction of experimental autoimmune encephalomyelitis

Yasuyuki Kihara et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Article Biochemistry & Molecular Biology

Exosome Secretion Ameliorates Lysosomal Storage of Cholesterol in Niemann-Pick Type C Disease

Katrin Strauss et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

Nobuyoshi Kosaka et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Cell Biology

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C

Chieh Hsu et al.

JOURNAL OF CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins

Caroline Subra et al.

JOURNAL OF LIPID RESEARCH (2010)

Article Multidisciplinary Sciences

Molecular mechanism of multivesicular body biogenesis by ESCRT complexes

Thomas Wollert et al.

NATURE (2010)

Article Cell Biology

Rab27a and Rab27b control different steps of the exosome secretion pathway

Matias Ostrowski et al.

NATURE CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

Vandhana Muralidharan-Chari et al.

CURRENT BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Acid sphingomyelinase activity triggers microparticle release from glial cells

Fabio Bianco et al.

EMBO JOURNAL (2009)

Article Multidisciplinary Sciences

High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients

Mariantonia Logozzi et al.

PLOS ONE (2009)

Review Cell Biology

Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes

Maria Yanez-Mo et al.

TRENDS IN CELL BIOLOGY (2009)

Review Immunology

Membrane vesicles as conveyors of immune responses

Clotilde Thery et al.

NATURE REVIEWS IMMUNOLOGY (2009)

Article Physiology

Aberrant catalytic cycle and impaired lipid transport into intracellular vesicles in ABCA3 mutants associated with nonfatal pediatric interstitial lung disease

Yoshihiro Matsumura et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)

Review Biochemistry & Molecular Biology

Biochemistry and physiology of mammalian secreted phospholipases A(2)

Gerard Lambeau et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2008)

Review Cell Biology

The sphingolipid salvage pathway in ceramide metabolism and signaling

Kazuyuki Kitatani et al.

CELLULAR SIGNALLING (2008)

Article Multidisciplinary Sciences

Ceramide triggers budding of exosome vesicles into multivesicular Endosomes

Katarina Trajkovic et al.

SCIENCE (2008)

Article Cell Biology

Lipids in dendritic cell biology: messengers, effectors, and antigens

Martin Thurnher

JOURNAL OF LEUKOCYTE BIOLOGY (2007)

Article Cell Biology

The multiple personalities of Alix

Greg Odorizzi

JOURNAL OF CELL SCIENCE (2006)

Article Immunology

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases

Suhayl Dhib-Jalbut et al.

JOURNAL OF NEUROIMMUNOLOGY (2006)

Article Biochemistry & Molecular Biology

Spontaneous curvature of phosphatidic acid and lysophosphatidic acid

EE Kooijman et al.

BIOCHEMISTRY (2005)

Article Biochemistry & Molecular Biology

A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation

DW Gilroy et al.

FASEB JOURNAL (2004)

Review Biochemistry & Molecular Biology

Acid and neutral sphingomyelinases: roles and mechanisms of regulation

N Marchesini et al.

BIOCHEMISTRY AND CELL BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Connection of lipid peroxide oxidation with the sphingomyelin pathway in the development of Alzheimer's disease

AV Alessenko et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2004)

Article Biochemistry & Molecular Biology

PLD2 is enriched on exosomes and its activity is correlated to the release of exosomes

K Laulagnier et al.

FEBS LETTERS (2004)

Article Immunology

Secretory phospholipase A2 induces dendritic cell maturation

L Perrin-Cocon et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2004)

Review Oncology

Biologically active sphingolipids in cancer pathogenesis and treatment

B Ogretmen et al.

NATURE REVIEWS CANCER (2004)

Article Neurosciences

Regulation of sphingomyelinases in cells of the oligodendrocyte lineage

FD Testai et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2004)

Article Pharmacology & Pharmacy

Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action

DS Menaldino et al.

PHARMACOLOGICAL RESEARCH (2003)

Review Biochemistry & Molecular Biology

Ceramide: second messenger or modulator of membrane structure and dynamics?

WJ van Blitterswijk et al.

BIOCHEMICAL JOURNAL (2003)

Review Biochemistry & Molecular Biology

Serine palmitoyltransferase: role in apoptotic de novo ceramide synthesis and other stress responses

DK Perry

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2002)

Review Immunology

Exosomes:: Composition, biogenesis and function

C Théry et al.

NATURE REVIEWS IMMUNOLOGY (2002)