Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 60, Issue 2, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijantimicag.2022.106615
Keywords
Antimicrobial resistance; Metallo-beta lactamase; Aminoglycosides; rmtC; armA; Neoglycosides
Funding
- Sapienza University of Rome , Top Scientist 1% Funds 2019 and Ateneo Funds 2021 [RM12117A70BE8124]
- Ateneo Funds [RM11916B6A8B5F8D]
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The spread of extremely-drug-resistant Klebsiella pneumoniae is a major global health threat, with high-risk clones playing a key role. It was found that New Delhi metallo (NDM) is often associated with 16S rRNA methyltransferases (16RMTases), both of which are spreading in K. pneumoniae.
The spread of extremely-drug-resistant Klebsiella pneumoniae has become a major health threat world-wide. This is largely mediated by certain lineages, recognized as high-risk clones dispersed throughout the world. Analysis of an outbreak of nine ST15, NDM-1 metallo-beta-lactamase-producing K. pneumoniae was performed. An IncC plasmid carrying the bla(NDM-1) gene also carried the rare rmtC gene, encoding for 16S rRNA methyltransferases (16RMTases), conferring resistance to all aminoglycosides. The global spread of New Delhi metallo (NDM) variants and their association with the 16RMTases among K. pneumoniae complete genomes available in GenBank was studied, and a complete overview of the association of 16RMTases and NDM in K. pneumoniae genomics was produced. NDM is often associated with16RMTases, and both are spreading in K. pneumoniae, conferring resistance to all beta-lactams and aminoglycosides. This analysis suggests that aminoglycosides have a limited future as a second-line treatment against NDM-producing K. pneumoniae. (c) 2022 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved.
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