Journal
BIOMOLECULES & THERAPEUTICS
Volume 22, Issue 1, Pages 27-34Publisher
KOREAN SOC APPLIED PHARMACOLOGY
DOI: 10.4062/biomolther.2013.092
Keywords
Curcumin; Mast cell; Prostaglandin D-2; Leukotriene C-4; Mitogen activated protein kinase; Passive systemic anaphylaxis
Funding
- Yeungnam University
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Curcumin is naturally occurring polyphenolic compound found in turmeric and has many pharmacological activities. The present study was undertaken to evaluate anti-allergic inflammatory activity of curcumin, and to investigate its inhibitory mechanisms in immunoglobulin E (IgE)/Ag-induced mouse bone marrow-derived mast cells (BMMCs) and in a mouse model of IgE/Ag-mediated passive systemic anaphylaxis (PSA). Curcumin inhibited cyclooxygenase-2 (COX-2) dependent prostaglandin D-2 (PGD(2)) and 5-lipoxygenase (5-LO) dependent leukotriene C-4 (LTC4) generation dose-dependently in BMMCs. To probe the mechanism involved, we assessed the effects of curcumin on the phosphorylation of Syk and its downstream signal molecules. Curcumin inhibited intracellular Ca2+ influx via phospholipase C gamma 1 (PLC gamma 1) activation and the phosphorylation of mitogen-activated protein kinases (MAPKs) and the nuclear factor-kappa B (NF-kappa B) pathway. Furthermore, the oral administration of curcumin significantly attenuated IgE/Ag-induced PSA, as determined by serum LTC4, PGD(2), and histamine levels. Taken together, this study shows that curcumin offers a basis for drug development for the treatment of allergic inflammatory diseases.
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