Journal
SCIENCE IMMUNOLOGY
Volume 7, Issue 73, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciimmunol.abq6509
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Funding
- German Research foundation [DFG RE 4468/1-1]
- National Institutes of Health [R35CA210098]
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CXCL9 and CXCL10, produced by antigen-presenting cells and tumor cells, co-localize with LAG3(+) T cells expressing CCL4 or CXCL13, contributing to the generation of a hot tumor microenvironment.
CXCL9 and CXCL10 can be produced by antigen-presenting cells (dendritic cells or macrophages) and by tumor cells. Hoch et al. demonstrated that CXCL9 and CXCL10 co-localize with LAG3(+) T cells expressing CCL4 or CXCL13 and contribute to the generation of a hot tumor microenvironment.
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