Journal
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
Volume 9, Issue 11, Pages 962-968Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.estlett.2c00650
Keywords
nanoplastics; microplastics; aging; weathering; corona
Categories
Funding
- National Natural Science Foundation of China
- [22176206]
- [21976145]
- [22174116]
- [21974110]
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UV and ozone aging treatments were found to oxidize polystyrene NPs, altering their adsorption characteristics towards plasma proteins and reducing cellular internalization of NPs, thus relieving their cytotoxic effects.
Humans are exposed to nanoplastics (NPs) through different routes, which raises critical concerns of related health effects. Due to their small sizes, NPs are accessible to the bloodstream and prone to interact with plasma proteins. NPs are susceptible to different aging processes before entering the human body, and it is plausible to evaluate the effect of aging on the physicochemical and biological properties of NPs. Here, we found that ultraviolet (UV) and ozone (O3) aging treatments caused the oxidation of polystyrene NPs, resulting in their differential adsorption characteristics toward plasma proteins. More impor-tantly, UV and O3 aging led to reduced cellular internalization of NPs and herein relieved their cytotoxic effect. Together, our current finding further enriches the understanding of NPs' toxicity in a realistic scenario.
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