Journal
BIOMOLECULES & THERAPEUTICS
Volume 21, Issue 5, Pages 323-331Publisher
KOREAN SOC APPLIED PHARMACOLOGY
DOI: 10.4062/biomolther.2013.072
Keywords
Transforming growth factor-beta (TGF-beta); EW-7197; ALK5; Breast cancer; Metastasis
Funding
- Korea Science and Engineering Foundation (KOSEF)
- Korea government (MEST) [20090093972]
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TGF-beta pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-beta (TGF-beta) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-beta related functional contexts. This review discusses the molecular mechanism of the TGF-beta pathway and describes the different ways of tumor suppression and promotion by TGF-beta. In the last part of the review, the data on targeting TGF-beta pathway for cancer treatment is assessed. The TGF-beta inhibitors in pre-clinical studies, and Phase I and II clinical trials are updated.
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