Lipids, Lipid-Lowering Therapy, and Neuropathy: A Narrative Review

Statins, or 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are the mainstay of treatment for hypercholesterolemia as they effectively reduce LDL-C levels and risk of atherosclerotic cardiovascular disease. Apart from hyperglycemia, dyslipidemia and HDL dysfunction are known risk factors for neuropathy in people with obesity and diabetes. Although there are case reports of statin-induced neuropathy, ad hoc analyses of clinical trials and observational studies have shown that statins may improve peripheral neuropathy. However, large randomized controlled trials and meta-analyses of cardiovascular outcome trials with statins and other lipid-lowering drugs have not reported on neuropathy outcomes. Because neuropathy was not a prespecified outcome in major cardiovascular trials, one cannot conclude whether statins or other lipid-lowering therapies increase or decrease the risk of neuropathy. The aim of this review was to assess if statins have beneficial or detrimental effects on neuropathy and whether there is a need for large well-powered interventional studies using objective neuropathy end points. (C) 2022 Published by Elsevier Inc.

Automated summary

This review article discusses the impact of statins on neuropathy, with some clinical trials and observational studies suggesting that statins may improve peripheral neuropathy. However, there is currently no large-scale randomized controlled trial or meta-analysis showing the effect of statins on neuropathy. Therefore, the need for further large-scale studies to evaluate the impact of statins on neuropathy remains a topic for discussion.