Journal
JOURNAL OF TISSUE VIABILITY
Volume 31, Issue 3, Pages 485-490Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jtv.2022.04.001
Keywords
Wound healing; Tropoelastin; Biomimetic; Tissue engineering; Electrospinning
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The research aims to modulate the wound healing cascade using acellular scaffolds, which are designed to create an acellular electrospun dermal biomimetic. Results showed that treated wounds had enhanced re-epithelialization, thicker epidermis, and new elastin fibers, indicating accelerated wound healing.
Aim: Tissue engineering has historically involved research combining scaffolds, cells, and active biomolecules to treat multiple pathologies. The current research seeks to determine if the wound healing cascade can be modulated using acellular scaffolds, engineered to create an acellular electrospun dermal biomimetic. Methods: The dermal biomimetic has a similar architecture to the dermis, porosity and fiber diameter, as well as physiologically relevant ratios of the primary structural dermal proteins, collagen and tropoelastin. This bio-mimetic wound healing device (BMWHD) was implanted into a full thickness dermal wound murine model for six days.Results: WHD-treated wounds had 30% greater re-epithelialization with a thicker epidermis, new elastin fibers in the wound bed, and healed architecture that matched unwounded extracellular matrix. Conclusions: Using these WHDs that closely match the native architecture and protein concentrations, accelerated the wound through the wound healing cascade and supports the hypothesis that structure alone can influence function when engineering acellular dermal biomimetic devices.
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