Journal
BIOMOLECULES & THERAPEUTICS
Volume 16, Issue 4, Pages 356-363Publisher
KOREAN SOC APPLIED PHARMACOLOGY
DOI: 10.4062/biomolther.2008.16.4.356
Keywords
Sponge-associated; Psychrobacter sp.; Cyclic dipeptide; D-proline; Vibrio vulnificus-induced cytotoxicity
Funding
- Ministry of Land, Transport, and Maritime Affairs, Korea
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A bacterial strain with good antibacterial activities against Staphylococus aureus and Escherichia coli was isolated from a marine sponge Stelleta sp., and it was identified as a Psychrobacter sp. by comparative 16S rDNA sequence analysis. In our search for bioactive secondary metabolites from this psychrophillic and halotolerent bacterium, sixteen cyclic dipeptides (1-16) were isolated and their structures were identified on the basis of NMR analysis. In the test of the compounds for the protective effect against Vibrio vulnificus-induced cytotoxicity in human intestinal epithelial cells, cyclo-(L-Pro-L-Phe) (5) exhibited significant protective effect. Compounds 2, 6, and 11, which contain D-amino acid, were first isolated from bacteria.
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