Journal
BIOMOLECULAR NMR ASSIGNMENTS
Volume 4, Issue 2, Pages 215-217Publisher
SPRINGER
DOI: 10.1007/s12104-010-9251-8
Keywords
Apoptosis; Neurotrophic factors; Parkinson's disease; NMR assignments
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Funding
- Academy of Finland [122170, 131144]
- Academy of Finland (AKA) [131144, 122170, 122170, 131144] Funding Source: Academy of Finland (AKA)
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Parkinson's disease (PD) is a chronic, progressive neurodegenerative disease, where dopaminergic cells die most prominently in the area of substantia nigra. Neurotrophic factors (NTFs) are secreted proteins, which upon binding to their target receptors trigger survival pathways to prevent neuronal loss. Recently discovered NTFs mesencephalic astrocyte-derived neurotrophic factor (MANF) and conserved dopamine neurotrophic factor (CDNF) most efficiently protect and repair the dopaminergic neurons in the animal 6-OHDA models of PD. However, the neuroprotective mechanism of MANF/CDNF is currently elusive. To this end, we have employed high-resolution NMR spectroscopy to determine three-dimensional structure of full-length human MANF in solution and characterized C-terminal domain as structural unit of MANF protein.
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