Journal
BIOMOLECULAR NMR ASSIGNMENTS
Volume 3, Issue 1, Pages 49-52Publisher
SPRINGER
DOI: 10.1007/s12104-008-9139-z
Keywords
Complement; Membrane attack complex; MAC; C7; Factor I module; FIM; NMR; Resonance assignment
Categories
Funding
- Medical Research Council of the U. K. [G0500940]
- The Wellcome Trust
- National Institute of Health [GM29831]
- MRC [G0500940] Funding Source: UKRI
- Medical Research Council [G0500940] Funding Source: researchfish
Ask authors/readers for more resources
The carboxy terminus of human complement component C7 comprises two Factor I-like Modules (FIMs) which are essential for formation of the Membrane Attack Complex, the terminal pathway of the innate immune system. C7-FIMs is a 16.9 kDa, recombinant, disulphide-rich, protein encompassing this C-terminal domain. Using conventional triple resonance experiments 93% of the H-1, N-15 and C-13 assignment has been achieved, accounting for all assignment apart from a flexible N-terminus cloning artefact and an undefined loop. The chemical shifts have been deposited in the BioMagResBank; Accession No. 15996.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available