Journal
BIOMICROFLUIDICS
Volume 8, Issue 5, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.4897913
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Funding
- EPSRC grant Large Scale Lattice Boltzmann for Biocolloidal Systems [EP/I034602/1]
- EC-FP7 project CRESTA [287703]
- University of Edinburgh
- UCL EPSRC Strategic Enterprise Award [GR/T11364/01]
- Engineering and Physical Sciences Research Council [EP/L00030X/1, EP/I034602/1] Funding Source: researchfish
- EPSRC [EP/L00030X/1, EP/I034602/1] Funding Source: UKRI
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We show, via three-dimensional immersed-boundary-finite-element-lattice-Boltzmann simulations, that deformability-based red blood cell (RBC) separation in deterministic lateral displacement (DLD) devices is possible. This is due to the deformability-dependent lateral extension of RBCs and enables us to predict a priori which RBCs will be displaced in a given DLD geometry. Several diseases affect the deformability of human cells. Malaria-infected RBCs, for example, tend to become stiffer than their healthy counterparts. It is therefore desirable to design microfluidic devices which can detect diseases based on the cells' deformability fingerprint, rather than preparing samples using expensive and time-consuming biochemical preparation steps. Our findings should be helpful in the development of new methods for sorting cells and particles by deformability. (C) 2014 AIP Publishing LLC.
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