Journal
BIOMICROFLUIDICS
Volume 7, Issue 1, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.4774308
Keywords
biomechanics; biomedical equipment; bioMEMS; blood; cancer; cellular biophysics; hydrodynamics; microfluidics; tumours
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Funding
- National Natural Science Foundation of China [61106128]
- Knowledge Innovation Project of the Chinese Academy of Science [KGCX2-YW-904]
- Guangdong Innovation Research Team Fund for Low-cost Healthcare Technologies (GIRTF-LCHT)
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This work reports a microfluidic device with deterministic lateral displacement (DLD) arrays allowing rapid and label-free cancer cell separation and enrichment from diluted peripheral whole blood, by exploiting the size-dependent hydrodynamic forces. Experiment data and theoretical simulation are presented to evaluate the isolation efficiency of various types of cancer cells in the microfluidic DLD structure. We also demonstrated the use of both circular and triangular post arrays for cancer cell separation in cell solution and blood samples. The device was able to achieve high cancer cell isolation efficiency and enrichment factor with our optimized design. Therefore, this platform with DLD structure shows great potential on fundamental and clinical studies of circulating tumor cells. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4774308]
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