Journal
BIOMICROFLUIDICS
Volume 6, Issue 1, Pages -Publisher
AIP Publishing
DOI: 10.1063/1.3687399
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Funding
- National Hi-Tech Program of China [2006AA020701]
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Here, we report a novel method for the fabrication of polydimethylsiloxane microdevices with complicated 3-D structures, such as concave and crater shapes, using an easily machined polymethyl methacrylate mold combined with a one-step molding process. The procedure presented here enables rapid preparation of complex 3-D microstructures varying in shape and dimensions. To regulate embryoid body (EB) formation, we fabricated a microfluidic device with an array of concave microwells and found that EBs growing in microwells maintained their shape, viability, and a high degree of homogeneity. We believe that this novel method provides an alternative for rapid prototyping, especially in fabricating devices with curved 3-D microstructures. (C) 2012 American Institute of Physics. [doi:10.1063/1.3687399]
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