Journal
BIOMICROFLUIDICS
Volume 6, Issue 2, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.4709387
Keywords
bioMEMS; cellular transport; electrochemical electrodes; electrophoresis; microchannel flow
Categories
Funding
- American Physical Society (APS)
- Natural Sciences and Engineering Research Council (NSERC)
- Canada Foundation for Innovation (CFI)
- Province of Manitoba
- Western Economic Diversification Canada (WD)
- Canadian Microelectronics Corporation (CMC) Microsystems
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Dielectric particles flowing through a microfluidic channel over a set of coplanar electrodes can be simultaneously capacitively detected and dielectrophoretically (DEP) actuated when the high (1.45 GHz) and low (100 kHz-20 MHz) frequency electromagnetic fields are concurrently applied through the same set of electrodes. Assuming a simple model in which the only forces acting upon the particles are apparent gravity, hydrodynamic lift, DEP force, and fluid drag, actuated particle trajectories can be obtained as numerical solutions of the equations of motion. Numerically calculated changes of particle elevations resulting from the actuation simulated in this way agree with the corresponding elevation changes estimated from the electronic signatures generated by the experimentally actuated particles. This verifies the model and confirms the correlation between the DEP force and the electronic signature profile. It follows that the electronic signatures can be used to quantify the actuation that the dielectric particle experiences as it traverses the electrode region. Using this principle, particles with different dielectric properties can be effectively identified based exclusively on their signature profile. This approach was used to differentiate viable from non-viable yeast cells (Saccharomyces cerevisiae). (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4709387]
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