Journal
BIOMICROFLUIDICS
Volume 5, Issue 1, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.3553237
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Funding
- National Science Foundation [EFRI-0735997]
- Draper Laboratories, Inc.
- Singapore-MIT Alliance for Research and Technology (SMART)
- NIBIB [EB003805]
- Anonymous Foundations
- Korea University
- KAKENHI [22680037]
- [DL-H-550151]
- Grants-in-Aid for Scientific Research [22680037] Funding Source: KAKEN
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Microfluidic devices allow for precise control of the cellular and noncellular microenvironment at physiologically relevant length-and time-scales. These devices have been shown to mimic the complex in vivo microenvironment better than conventional in vitro assays, and allow real-time monitoring of homotypic or heterotypic cellular interactions. Microfluidic culture platforms enable new assay designs for culturing multiple different cell populations and/or tissue specimens under controlled user-defined conditions. Applications include fundamental studies of cell population behaviors, high-throughput drug screening, and tissue engineering. In this review, we summarize recent developments in this field along with studies of heterotypic cell-cell interactions and tissue specimen culture in microfluidic devices from our own laboratory. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3553237]
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