Journal
MATERIALS LETTERS
Volume 325, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.matlet.2022.132804
Keywords
Polymeric composites; Fibre technology; Drug release; Antibacterial nano-ZnO
Funding
- National Natural Science Foundation of China [21706043]
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The coaxial electrospinning technique was used to prepare core-shell fibers with clear core-shell structure and nano-ZnO, resulting in lower initial drug release and antibacterial activity against E. coli and S. aureus.
The coaxial electrospinning was used to prepare Voltaren-loaded and nano-ZnO-loaded core-shell polylactic acid (PLA)/silk fibroin (SF) fibers. The elemental morphology, compositions, the release behavior and the antibacterial property of the fibers were investigated. The result showed that the fibers had a clear core-shell structure and nano-ZnO was observed in the shell. The cumulative drug release rates of core-shell fibers were 48.8% and 72.6% at 100 min and 600 min, respectively. The core-shell PLA/SF had a smaller initial release of Voltaren and an obvious antibacterial activity against Escherichia coli and Staphylococcus aureus under an absence of light.
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