Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 28, Issue 5, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202103566
Keywords
bioorganometallics; rhenium; sandwich complexes; technetium; theranostics
Categories
Funding
- University of Zurich
- Universitat Zurich
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A new synthesis method for sandwich type complexes, including functionalized arenes and pharmaceuticals, paves the way for molecular theranostics.
Bis-arene sandwich complexes are generally prepared by the Fischer-Hafner reaction, which conditions are incompatible with most Q- and N- functional groups. We report a new way for the synthesis of sandwich type complexes [Re(eta(6)-arene)(2)](+) and [Re(eta(6)-arene)(eta(6)-benzene)](+) from [Re(eta(6)-napht)(2)](+) and [Re(eta(6)-napht)(eta(6)-benzene)](+), with functionalized arenes and pharmaceuticals. N-methylpyrrolidine (NMP) facilitates the substitution of naphthalene with the incoming arene. A series of fully characterized rhenium sandwich complexes with simple arenes, such as aniline, as well as with active compounds like lidocaine and melatonin are presented. With these rhenium compounds in hand, the radioactive sandwich complexes [Tc-99m(eta(6)-pharm)(2)](+) (pharm= pharmaceutical) can be unambiguously confirmed. The direct labelling of pharmaceuticals with Tc-99(m) through eta(6)-coordination to phenyl rings and the confirmation of the structures with the rhenium homologues opens a path into molecular theranostics.
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