Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 10, Issue 1, Pages 49-51Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(99)00572-7
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A series of pharmacologically active, functionalized 4-aryl-3,4-dihydropyrimidine-5-carboxylates (DHPMs) are prepared by a versatile novel solid phase approach. In the key step, a polymer-bound thiouronium salt is condensed with unsaturated beta-ketoesters. The resulting polymer bound 1,4-dihydropyrimidines are cleaved from the resin employing multidirectional resin cleavage strategies. (C) 1999 Elsevier Science Ltd. All rights reserved.
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