Journal
BRAIN RESEARCH
Volume 852, Issue 1, Pages 217-220Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(99)02140-X
Keywords
osteopontin; ganglion cells; axotomy; retina; rat
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Funding
- NICHD NIH HHS [N01-HD-2-3144] Funding Source: Medline
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Osteopontin (OPN) is a negatively charged, highly acidic glycosylated phosphoprotein that contains an GRGDS amino acid sequence, characteristic of proteins that bind to integrin receptors, thereby playing crucial roles in a number of physiological processes. This study was conducted to examine the expression of OPN in the rat retina by Northern blot analysis, Western blot analysis and immunocytochemistry. The expression of OPN was identified in the retina and OPN-like immunoreactivity was present in a number of ganglion cells. Thus, OPN appears to be important in the retinal homeostasis. (C) 2000 Elsevier Science B.V. All rights reserved.
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