Journal
JOURNAL OF CONTROLLED RELEASE
Volume 63, Issue 1-2, Pages 155-163Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0168-3659(99)00194-7
Keywords
biodegradable hydrogel; injectable formulation; sol-gel transition; in situ gel; drug release model
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An aqueous solution of newly developed low-molecular-weight PEG-PLGA-PEG triblock copolymers with a specific composition is a free flowing sol at room temperature but becomes a gel at body temperature. Two model drugs, ketoprofen and spironolatone, which have different hydrophobicities, were released from the PEG-PLGA-PEG triblock copolymer hydrogel formed in situ by injecting the solutions into a 37 degrees C aqueous environment. Ketoprofen (a model hydrophilic drug) was released over 2 weeks with a first-order release profile, while spironolactone (a model hydrophobic drug) was released over 2 months with an S-shaped release profile. The release profiles were simulated by models considering degradation and diffusion, and were better described by a model assuming a core-shell structure of the gel. (C) 2000 Published by Elsevier Science B.V. All rights reserved.
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