Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 267, Issue 1, Pages 245-251Publisher
ACADEMIC PRESS INC
DOI: 10.1006/bbrc.1999.1840
Keywords
thromboxane A(2) (TXA(2)); angiogenesis; eicosanoid; endothelial cell; tumor metastasis
Categories
Funding
- NCI NIH HHS [CA-29997] Funding Source: Medline
Ask authors/readers for more resources
Prostaglandin endoperoxide H synthases and their arachidonate products have been implicated in modulating angiogenesis during tumor growth and chronic inflammation, Here we report the involvement of thromboxane A(2), a downstream metabolite of prostaglandin H synthase, in angiogenesis, A TXA(2) mimetic, U46619, stimulated endothelial cell migration. Angiogenic basic fibroblast growth factor (bFGF) or vascular endothelial growth factor (VEGF) increased TXA(2) synthesis in endothelial cells three- to fivefold. Inhibition of TXA(2) synthesis with furegrelate or CI reduced HUVEC migration stimulated by VEGF or bFGF, A TXA(2) receptor antagonist, SQ29,548, inhibited VEGF- or bFGF-stimulated endothelial cell migration, In vivo CI inhibited bFGF-induced angiogenesis, Finally, development of lung metastasis in C57B1/6J mice intravenously injected with Lewis lung carcinoma or B16a cells was significantly inhibited by thromboxane synthase inhibitors, CI or furegrelate sodium, Our data demonstrate the involvement of TXA(2) in angiogenesis and development of tumor metastasis, (C) 2000 Academic Press.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available