Journal
NEUROSCIENCE LETTERS
Volume 278, Issue 1-2, Pages 105-108Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(99)00907-6
Keywords
aging; chemical derivatization; lipid peroxides; high performance liquid chromatography; 1-naphthyldiphenylphosphine; 1-naphthyldiphenylphosphine oxide; senescence-accelerated mice
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The tissue concentration of lipid peroxides was determined in the brain, heart, liver, lung and kidney of accelerated senescence-prone (SAMP-8) and -resistant (SAMR-1) mice at 3, 6 and 9 months of age by a method involving chemical derivatization and high performance liquid chromatography. The level of lipid peroxides in the brain did not show an age-dependent change, but at each age the brain level of lipid peroxides was significantly higher in SAMP-8 than in SAMR-1. In contrast, the lipid peroxide levels in the peripheral organs showed increases with aging in both strains, and they were significantly higher in SAMP-8 than in SAM R-1 at both 3 and 6 months of age (except at 3 months of age in the kidney). These results suggest that increased oxidative stress in the brain and peripheral organs is a cause of the senescence-related degeneration and impairments seen in SAMP-8. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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