Journal
SCIENCE
Volume 287, Issue 5450, Pages 125-128Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.287.5450.125
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Leptin, a hormone secreted by fat cells, suppresses food intake and promotes weight Loss, To assess the action of this hormone on brain reward circuitry, changes in the rewarding effect of Lateral hypothalamic stimulation were measured after leptin administration. At five stimulation sites near the fornix, the effectiveness of the rewarding electrical stimulation was enhanced by chronic food restriction and attenuated by intracerebroventricular infusion of leptin. In contrast, the rewarding effect of stimulating neighboring sites was insensitive to chronic food restriction and was enhanced by leptin in three of four cases. These opposing effects of Leptin may mirror complementary changes in the rewarding effects of feeding and of competing behaviors.
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