4.4 Article

Synthesis of functional bisphosphonates via new palladium-catalyzed bis-hydrophosphorylation reactions

Journal

TETRAHEDRON LETTERS
Volume 41, Issue 2, Pages 151-154

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(99)02042-0

Keywords

palladium catalysts; phosphorylation; alkynes

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A series of functional bisphosphonates have been synthesized in good isolated yields via new palladium-catalyzed bis-hydrophosphorylation reactions of terminal alkynes and dialkyl phosphites. The scope and mechanism for such a bis-hydrophosphorylation process are also discussed. (C) 1999 Elsevier Science Ltd. All rights reserved.

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