Journal
NEUROLOGY
Volume 54, Issue 1, Pages 236-239Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.54.1.236
Keywords
axonal injury; MS; functional MRI; plasticity; spectroscopy
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A patient was followed after the new onset of hemiparesis from relapse of MS with serial MR spectroscopy and functional MRI. The association of clinical improvement with recovery of N-acetylaspartate, a marker of neuronal integrity, and progressive reduction of abnormally large functional MRI cortical activation with movement demonstrates that dynamic reorganization of the motor cortex accompanies remission of MS.
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