Journal
SCIENCE
Volume 287, Issue 5451, Pages 321-324Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.287.5451.321
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CD9 is an integral membrane protein associated with integrins and other membrane proteins, Mice lacking CD9 were produced by homologous recombination. Both male and female CD9(-/-) mice were born healthy and grew normally, However, the litter size from CD9(-/-) females was less than 2% of that of the wild type. In vitro fertilization experiments indicated that the cause of this infertility was due to;the failure of sperm-egg fusion. When sperm were injected into oocytes with assisted microfertilization techniques, however, the fertilized eggs developed to term. These results indicate that CD9 has a crucial role in sperm-egg fusion.
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