Journal
NEUROSCIENCE LETTERS
Volume 278, Issue 3, Pages 145-148Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(99)00935-0
Keywords
midline thalamus; hippocampus; anterograde tracing; interneuron; gamma aminobutyric acid; ultrastructure
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The aim of the present study was to investigate whether the nucleus reuniens thalami (RE) innervates inhibitory cells in hippocampal field CA1. Therefore, we examined the RE-CA1 input at the ultrastructural level. RE axons were anterogradely labeled with biotin-conjugated dextran amine [BDA], in combination with pre-embedding gamma aminobutyric acid (GABA)-immunolabeling of neurons in CA1. We observed that part of the BDA-labeled axons formed asymmetrical (i.e. excitatory) synapses on GABA-positive dendrites. Based on these data, which are in line with our previously published electrophysiological observations (Dolleman-Van der Weer, M.J., Lopes da Silva, F.H, and Witter, M.P., Nucleus reuniens thalami modulates activity in hippocampal field CA1 through excitatory and inhibitory mechanisms. J. Neurosci., 17 (1997) 5640-5650), we propose that RE-CA1 input partially influences hippocampal transmission through activation of local inhibitory interneurons. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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