Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 19, Issue 10, Pages 2324-2328Publisher
WILEY
DOI: 10.1111/jcmm.12633
Keywords
doxorubicin; cardiotoxicity; resveratrol; ROS; apoptosis; autophagy
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Funding
- Shanghai Science and Technology Commission [14411972900]
- Shanghai City Key Medical Specialties [ZK2012A24]
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Doxorubicin is the mainstay of treatment for various haematological malignancies and solid tumours. However, its clinical application may be hampered by dose-dependent cardiotoxicity. The mechanism of doxorubicin-induced cardiotoxicity may involve various signalling pathways including free radical generation, peroxynitrite formation, calcium overloading, mitochondrial dysfunction and alteration in apoptosis and autophagy. Interestingly, the use of resveratrol in combination with doxorubicin has been reported to prevent cardiac toxicity as well as to exert a synergistic effect against tumour cells both invivo and invitro. Thus, the aim of this review is to summarize current knowledge and to elucidate the protective effect of resveratrol in doxorubicin-induced cardiotoxicity.
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