Journal
JOURNAL OF IMMUNOLOGY
Volume 164, Issue 2, Pages 986-993Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.164.2.986
Keywords
-
Categories
Funding
- NIAID NIH HHS [AI39614, AI27998] Funding Source: Medline
Ask authors/readers for more resources
CD4(+) T cells are important for resistance to infection with Salmonella typhimurium. However, the Ag specificity of this T cell response is unknown, Here, we demonstrate that a significant fraction of Salmonella-specific CD4(+) T cells respond to the flagellar filament protein, FliC, and that this Ag has the capacity to protect naive mice from lethal Salmonella infection, To characterize this Ag-specific response further, we generated FliC-specific CD4+ T cell clones from mice that had resolved infection with an attenuated strain of Salmonella. These clones were found to respond to an epitope from a constant region of FliC, enabling them to cross-react with flagellar proteins expressed by a number of distinct Salmonella serovars.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available