Journal
BIOCHEMICAL JOURNAL
Volume 345, Issue -, Pages 181-184Publisher
PORTLAND PRESS
DOI: 10.1042/0264-6021:3450181
Keywords
ecto-enzyme; glycosylation; lysophosphatidate; phosphatidate phosphohydrolase
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Lipid phosphate phosphatase-1 (LPP-1) dephosphorylates exogenous lysophosphatidate and thereby regulates the activation of lysophosphatidate receptors and cell division. Mutation of seven amino acids in three conserved domains of mouse LPP-1 abolished its activity. A glycosylation site was demonstrated between conserved Domains 1 and 2. LPP-1 is expressed in the plasma membrane, and the present results demonstrate the active site to be located on the outer surface.
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