Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 267, Issue 2, Pages 593-596Publisher
ACADEMIC PRESS INC
DOI: 10.1006/bbrc.1999.1991
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GADD34 is one of a subset of proteins induced after DNA damage or cell growth arrest, To examine the function of GADD34, we used the yeast two-hybrid system to clone the protein that interacts with the murine GADD34. One cDNA clone was the C-terminal part of KIF3A gene including the tail domain. The interaction between GADD34 and KIF3A was confirmed in the NIH3T3 cells by in vivo two-hybrid analysis. We could detect that GADD34 was induced with methyl methanesulfonate; however, the mRNA induction of KIF3A was not detected, (C) 2000 Academic Press.
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