Journal
FEBS LETTERS
Volume 466, Issue 1, Pages 143-147Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(99)01777-9
Keywords
endothelial monocyte-activating polypeptide II; caspase-7; apoptosis; leukocyte recruitment
Ask authors/readers for more resources
Endothelial monocyte-activating polypeptide II (EMAP II) is a proinflammatory cytokine and a chemoattractant for leukocytes. The mature cytokine is formed in apoptotic cells by cleavage of the precursor proEMAP II. Here we show that caspase-7 is capable of cleaving proEMAP II in vitro. A proEMAP II mutant, in which the ASTD cleavage site was changed to the sequence ASTA, was not processed by caspase-7. The caspase-7-mediated generation and release of mature EMAP II may provide a mechanism for leukocyte recruitment to sites of programmed cell death, and thus may link apoptosis to inflammation. (C) 2000 Federation of European Biochemical Societies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available