Journal
BIOMETALS
Volume 26, Issue 4, Pages 537-547Publisher
SPRINGER
DOI: 10.1007/s10534-013-9629-z
Keywords
Iron transport; Siderophore; Evolution; Anguibactin; Vibrio anguillarum; Vibrio harveyi
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Funding
- NIAID NIH HHS [R01 AI019018, R01 AI070174, AI070174, AI19018] Funding Source: Medline
- NIGMS NIH HHS [GM64600, R01 GM064600] Funding Source: Medline
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Vibrio anguillarum is a marine pathogen that causes vibriosis, a hemorrhagic septicemia in aquatic invertebrate as well as vertebrate animals. The siderophore anguibactin system is one of the most important virulence factors of this bacterium. Most of the anguibactin biosynthesis and transport genes are located in the 65-kb pJM1 virulence plasmid although some of them are found in the chromosome of this fish pathogen. Over 30 years of research unveiled the role numerous chromosomal and pJM1 genes play in the synthesis of anguibactin and the transport of cognate ferric complexes into the bacterial cell. Furthermore, these studies showed that pJM1-carrying strains might be originated from pJM1-less strains producing the chromosome-mediated siderophore vanchrobactin. Additionally, we recently identified a chromosome-mediated anguibactin system in V. harveyi suggesting the possible evolutional origin of the V. anguillarum anguibactin system. In this review, we present our current understanding of the mechanisms and evolution hypothesis of the anguibactin system that might have occurred in these pathogenic vibrios.
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