Journal
BRAIN RESEARCH
Volume 853, Issue 2, Pages 377-380Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(99)02237-4
Keywords
human; substantia nigra; ventral tegmental area; oculomotor nucleus; serotonin 2A receptor; serotonin; tyrosine hydroxylase; dopamine; immunohistochemistry
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We demonstrated intense serotonin (5-HT) 2A receptor immunoreactivity in the human ventral tegmental area (VTA) using by a recently raised antibody against 5-HT2A receptor. The substantia nigra (SN) neurons also showed 5-HT2A receptor immunoreactivity. Double immunohistochemistry of 5-HT2A receptor and tyrosine hydroxylase (TH) revealed many neurons doubly labeled by 5-HT2A receptor and TH in the VTA and SN. It is suggested that activity of human midbrain dopaminergic neurons might be strongly regulated via 5-HT2A receptors at the level of their originating nuclei. (C) 2000 Elsevier Science B.V. All rights reserved.
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