Journal
NATURE
Volume 403, Issue 6768, Pages 385-389Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/35000126
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Communication between cells during early embryogenesis establishes the basic organization of the vertebrate body plan. Recent work suggests that a signalling pathway centering on Nodal, a transforming growth factor P-related signal, is responsible for many of the events that configure the vertebrate embryo. The activity of Nodal signals is regulated extracellularly by EGF-CFC cofactors and antagonists of the Lefty and Cerberus families of proteins, allowing precise control of mesoderm and endoderm formation, the positioning of the anterior-posterior axis, neural patterning and left-right axis specification.
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