4.8 Article

Ubiquitination: RING for destruction?

Journal

CURRENT BIOLOGY
Volume 10, Issue 2, Pages R84-R87

Publisher

CURRENT BIOLOGY LTD
DOI: 10.1016/S0960-9822(00)00287-6

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Ubiquitination targets proteins for degradation and is a potent regulator of cellular protein function. Recent results implicate the RING finger domain in specific ubiquitination events; it is possible that all RING proteins act as E3 ubiquitin protein ligases, with implications for a variety of biological areas.

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