Journal
BIOMETALS
Volume 22, Issue 4, Pages 583-593Publisher
SPRINGER
DOI: 10.1007/s10534-009-9236-1
Keywords
Iron; Antibiotic; Siderophore
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Funding
- NIEHS NIH HHS [R03 ES014390] Funding Source: Medline
- NIGMS NIH HHS [R01 GM090260] Funding Source: Medline
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Iron is essential for the survival of most organisms. Microbial iron acquisition depends on multiple, sometimes complex steps, many of which are not shared by higher eukaryotes. Depriving pathogenic microbes of iron is therefore a potential antimicrobial strategy. The following minireview briefly describes general elements in microbial iron uptake pathways and summarizes some of the current work aiming at their medicinal inhibition.
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