Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 12, Issue 1, Pages 59-63Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0952-7915(99)00051-5
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IL-18 - a novel cytokine with potent IFN-gamma-inducing activities - plays an important role in the Th1-mediated immune response in collaboration with IL-12. IL-18 is a member of the IL-1 family. The IL-18 receptor system and its signal transduction pathway are analogous to those of the IL-1 receptor. Mice deficient in IL-18 have demonstrated its critical role in natural killer cell activity and in vivo Th1 response.
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