Journal
INFECTION AND IMMUNITY
Volume 68, Issue 2, Pages 982-985Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.68.2.982-985.2000
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Funding
- NIAID NIH HHS [R01 AI039115, R01AI39115, P01 AI044975, AI41937, AI42159, R01 AI042159] Funding Source: Medline
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The calcineurin gene was cloned and disrupted in serotype D strains of Cryptococcus neoformans. Serotype A and serotype D calcineurin mutants were inviable at 37 degrees C and avirulent in mice, whereas only serotype A mutants were cation stress sensitive. Thus, calcineurin plays conserved and divergent roles in serotype A and serotype D strains.
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