Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 12, Issue 1, Pages 97-103Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0955-0674(99)00062-9
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Funding
- NIGMS NIH HHS [R01 GM047337-07, R01 GM038542-11S1] Funding Source: Medline
- PHS HHS [38542] Funding Source: Medline
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The most important discovery in the field is that the Arp2/3 complex nucleates assembly of actin filaments with free barbed ends. Arp2/3 also binds the sides of actin filaments to create a branched network. Arp2/3's nucleation activity is stimulated by WASP family proteins, some of which mediate signaling from small G-proteins. Listeria movement caused by actin polymerization can be reconstituted in vitro using purified proteins: Arp2/3 complex, capping protein, actin depolymerizing factor/cofilin, and actin. actin depolymerizing factor/cofilin increases the rate at which actin subunits leave pointed ends, and capping protein caps barbed ends.
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