Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 10, Issue 1, Pages 146-152Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-4388(99)00061-6
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Funding
- NIDA NIH HHS [R01 DA09862] Funding Source: Medline
- NIMH NIH HHS [MH01711-01] Funding Source: Medline
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With the advent of gene knockout technology has arisen the problem of how to interpret the resulting phenotypic changes in mice lacking specific genes. This problem is especially relevent when applied to behavioral phenotypes of knockout mice, which are difficult to interpret. Of particular interest are the roles of development and compensatory changes, as well as other factors, such as the influence of the gene knockout on nearby genes, the effect of the genetic background strain, maternal behavioral influences, and pleiotrophy.
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