Journal
JOURNAL OF CELL SCIENCE
Volume 128, Issue 16, Pages 2957-2964Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.156398
Keywords
Rab; Ral; Rho; Exocyst; Membrane fusion; Vesicle tether
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Funding
- National Institute of General Medical Sciences [GM085146, GM111128]
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The exocyst is an octameric protein complex that is implicated in the tethering of secretory vesicles to the plasma membrane prior to SNARE-mediated fusion. Spatial and temporal control of exocytosis through the exocyst has a crucial role in a number of physiological processes, such as morphogenesis, cell cycle progression, primary ciliogenesis, cell migration and tumor invasion. In this Cell Science at a Glance poster article, we summarize recent works on the molecular organization, function and regulation of the exocyst complex, as they provide rationales to the involvement of this complex in such a diverse array of cellular processes.
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