Journal
ANTI-CANCER DRUGS
Volume 11, Issue 2, Pages 123-127Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001813-200002000-00009
Keywords
cancer; chemotherapy; doxorubicin; human; liposome; prostate
Categories
Ask authors/readers for more resources
Doxil, a doxorubicin formulation of polyethylene glycol-coated liposomes, has anti-tumor activity against Kaposi's sarcoma and other solid tumors with mild myelosuppression, minimal hair loss and a low risk of cardiotoxicity. Non-liposomal doxorubicin has modest activity in hormone-refractory prostate cancer (HRPC) with considerable toxicity. A pilot study of Doxil was conducted in 15 patients with HRPC. Doxil was administered i.v, using two regimes of equal dose intensity, either 45 mg/m(2) every 3 weeks or 60 mg/m(2) every 4 weeks, Plasma levels of doxorubicin were analyzed in 10 patients, The most common side effect was stomatitis with a higher incidence at the 60 mg/m(2) dose level. In contrast, hand-foot syndrome was more frequent and severe in patients treated with the 3 week schedule of 45 mg/m(2). Three patients responded to treatment (based on objective response in one patient and reduction of PSA level greater than 50% in the other two) and two patients had stable disease, all of them receiving 60 mg/m(2). Pharmacokinetic analysis shows a proportional increase of plasma drug levels with dose and the characteristic long circulation time of Doxil with half-lives in the range of 3 days, somewhat longer than previously reported, In conclusion, Doxil at 60 mg/m(2) every 4 weeks appears to be active against HRPC, but severe mucocutaneous toxicities prevented further investigation of this regime. [(C) 2000 Lippincott Williams & Wilkins.].
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available